Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Vsx2  visual system homeobox 2   (Synonyms: Chx10, Hox10, Hox-10)
Results	Reference
1	J:57340 Arber S, Han B, Mendelsohn M, Smith M, Jessell TM, Sockanathan S, Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron. 1999 Aug;23(4):659-74
1	J:87948 Bai CB, Stephen D, Joyner AL, All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell. 2004 Jan;6(1):103-15
1	J:158712 Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA, AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Hum Mol Genet. 2010 May 1;19(9):1791-804
1	J:83532 Baumer N, Marquardt T, Stoykova A, Spieler D, Treichel D, Ashery-Padan R, Gruss P, Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development. 2003 Jul;130(13):2903-15
1	J:32083 Burmeister M, Novak J, Liang MY, Basu S, Ploder L, Hawes NL, Vidgen D, Hoover F, Goldman D, Kalnins VI, Roderick TH, Taylor BA, Hankin MH, McInnes RR, Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet. 1996 Apr;12(4):376-84
1	J:249800 Burnett JB, Lupu FI, Eggenschwiler JT, Proper ciliary assembly is critical for restricting Hedgehog signaling during early eye development in mice. Dev Biol. 2017 Oct 1;430(1):32-40
1	J:299679 Debrulle S, Baudouin C, Hidalgo-Figueroa M, Pelosi B, Francius C, Rucchin V, Ronellenfitch K, Chow RL, Tissir F, Lee SK, Clotman F, Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development. Cell Mol Life Sci. 2020 Oct;77(20):4117-4131
1	J:176438 Esteve P, Sandonis A, Ibanez C, Shimono A, Guerrero I, Bovolenta P, Secreted frizzled-related proteins are required for Wnt/{beta}-catenin signalling activation in the vertebrate optic cup. Development. 2011 Oct;138(19):4179-84
1	J:240621 Francius C, Hidalgo-Figueroa M, Debrulle S, Pelosi B, Rucchin V, Ronellenfitch K, Panayiotou E, Makrides N, Misra K, Harris A, Hassani H, Schakman O, Parras C, Xiang M, Malas S, Chow RL, Clotman F, Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord. Front Mol Neurosci. 2016;9:145
1	J:153566 Fujimura N, Taketo MM, Mori M, Korinek V, Kozmik Z, Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium. Dev Biol. 2009 Oct 1;334(1):31-45
1	J:86041 Gaufo GO, Thomas KR, Capecchi MR, Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons. Development. 2003 Nov;130(21):5191-201
1	J:94724 Gotoh N, Ito M, Yamamoto S, Yoshino I, Song N, Wang Y, Lax I, Schlessinger J, Shibuya M, Lang RA, Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17144-9
1	J:76658 Gross MK, Dottori M, Goulding M, Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. Neuron. 2002 May 16;34(4):535-49
1	J:117093 Gui H, Li S, Matise MP, A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord. Dev Biol. 2007 Jan 1;301(1):14-26
1	J:260444 Hayashi M, Hinckley CA, Driscoll SP, Moore NJ, Levine AJ, Hilde KL, Sharma K, Pfaff SL, Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control. Neuron. 2018 Feb 21;97(4):869-884.e5
1	J:122547 Huang X, Litingtung Y, Chiang C, Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord. Development. 2007 Jun;134(11):2095-105
1	J:100466 Huangfu D, Anderson KV, Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11325-30
1	J:86437 Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV, Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003 Nov 6;426(6962):83-7
1	J:231979 Huettl RE, Eckstein S, Stahl T, Petricca S, Ninkovic J, Gotz M, Huber AB, Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development. Dev Biol. 2016 May 1;413(1):86-103
1	J:131816 Iulianella A, Sharma M, Durnin M, Vanden Heuvel GB, Trainor PA, Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis. Development. 2008 Feb;135(4):729-41
1	J:218198 Kaltezioti V, Antoniou D, Stergiopoulos A, Rozani I, Rohrer H, Politis PK, Prox1 regulates Olig2 expression to modulate binary fate decisions in spinal cord neurons. J Neurosci. 2014 Nov 19;34(47):15816-31
1	J:208421 Klimova L, Kozmik Z, Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
1	J:272124 Laumonnerie C, Tong YG, Alstermark H, Wilson SI, Commissural axonal corridors instruct neuronal migration in the mouse spinal cord. Nat Commun. 2015 May 11;6:7028
1	J:100591 Lee HY, Wroblewski E, Philips GT, Stair CN, Conley K, Reedy M, Mastick GS, Brown NL, Multiple requirements for Hes 1 during early eye formation. Dev Biol. 2005 Aug 15;284(2):464-78
1	J:198703 Lee S, Shen R, Cho HH, Kwon RJ, Seo SY, Lee JW, Lee SK, STAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11445-50
1	J:100187 Li S, Misra K, Matise MP, Xiang M, Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10688-93
1	J:166623 Li S, Misra K, Xiang M, A Cre transgenic line for studying V2 neuronal lineages and functions in the spinal cord. Genesis. 2010 Nov;48(11):667-72
1	J:118347 Liu B, Liu Z, Chen T, Li H, Qiang B, Yuan J, Peng X, Qiu M, Selective expression of Bhlhb5 in subsets of early-born interneurons and late-born association neurons in the spinal cord. Dev Dyn. 2007 Mar;236(3):829-35
1	J:246467 Liu W, Cvekl A, Six3 in a small population of progenitors at E8.5 is required for neuroretinal specification via regulating cell signaling and survival in mice. Dev Biol. 2017 Aug 01;428(1):164-175
1	J:165328 Liu W, Lagutin O, Swindell E, Jamrich M, Oliver G, Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate. J Clin Invest. 2010 Oct 1;120(10):3568-77
1*	J:75868 Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH, Common developmental requirement for olig function indicates a motor neuron/oligodendrocyte connection. Cell. 2002 Apr 5;109(1):75-86
1	J:257916 Lupu FI, Burnett JB, Eggenschwiler JT, Cell cycle-related kinase regulates mammalian eye development through positive and negative regulation of the Hedgehog pathway. Dev Biol. 2018 Feb 1;434(1):24-35
1	J:221029 Ma YC, Song MR, Park JP, Henry Ho HY, Hu L, Kurtev MV, Zieg J, Ma Q, Pfaff SL, Greenberg ME, Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron. 2008 Apr 10;58(1):65-77
1	J:156172 Marklund U, Hansson EM, Sundstrom E, de Angelis MH, Przemeck GK, Lendahl U, Muhr J, Ericson J, Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development. 2010 Feb;137(3):437-45
1*	J:49251 Matise MP, Epstein DJ, Park HL, Platt KA, Joyner AL, Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development. 1998 Aug;125(15):2759-70
1	J:109351 Miller LA, Smith AN, Taketo MM, Lang RA, Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice. BMC Dev Biol. 2006;6:14
1	J:206314 Misra K, Luo H, Li S, Matise M, Xiang M, Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFbeta signaling to specify V2b interneurons in the spinal cord. Development. 2014 Jan;141(1):187-98
1	J:70192 Moran-Rivard L, Kagawa T, Saueressig H, Gross MK, Burrill J, Goulding M, Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord. Neuron. 2001 Feb;29(2):385-99
1	J:150755 Oh S, Huang X, Liu J, Litingtung Y, Chiang C, Shh and Gli3 activities are required for timely generation of motor neuron progenitors. Dev Biol. 2009 Jul 15;331(2):261-9
1	J:164670 Panayi H, Panayiotou E, Orford M, Genethliou N, Mean R, Lapathitis G, Li S, Xiang M, Kessaris N, Richardson WD, Malas S, Sox1 is required for the specification of a novel p2-derived interneuron subtype in the mouse ventral spinal cord. J Neurosci. 2010 Sep 15;30(37):12274-80
1	J:74525 Parras CM, Schuurmans C, Scardigli R, Kim J, Anderson DJ, Guillemot F, Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev. 2002 Feb 1;16(3):324-38
1	J:84976 Pattyn A, Vallstedt A, Dias JM, Sander M, Ericson J, Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain. Development. 2003 Sep;130(17):4149-59
1	J:80207 Persson M, Stamataki D, te Welscher P, Andersson E, Bose J, Ruther U, Ericson J, Briscoe J, Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev. 2002 Nov 15;16(22):2865-78
1	J:158273 Ross SE, Mardinly AR, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Greenberg ME, Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010 Mar 25;65(6):886-98
1	J:70697 Scardigli R, Schuurmans C, Gradwohl G, Guillemot F, Crossregulation between Neurogenin2 and Pathways Specifying Neuronal Identity in the Spinal Cord. Neuron. 2001 Aug;31(2):203-17
1	J:158133 Smith AN, Miller LA, Radice G, Ashery-Padan R, Lang RA, Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis. Development. 2009 Sep;136(17):2977-85
1	J:157261 Smith AN, Radice G, Lang RA, Which FGF ligands are involved in lens induction?. Dev Biol. 2010 Jan 15;337(2):195-8
1	J:255241 Takata N, Abbey D, Fiore L, Acosta S, Feng R, Gil HJ, Lavado A, Geng X, Interiano A, Neale G, Eiraku M, Sasai Y, Oliver G, An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation. Cell Rep. 2017 Nov 7;21(6):1534-1549
1	J:157924 Tang K, Xie X, Park JI, Jamrich M, Tsai S, Tsai MJ, COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development. 2010 Mar;137(5):725-34
1	J:57339 Thaler J, Harrison K, Sharma K, Lettieri K, Kehrl J, Pfaff SL, Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9. Neuron. 1999 Aug;23(4):675-87
1	J:71607 Vallstedt A, Muhr J, Pattyn A, Pierani A, Mendelsohn M, Sander M, Jessell TM, Ericson J, Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification. Neuron. 2001 Sep 13;31(5):743-55
1	J:175801 Wang H, Lei Q, Oosterveen T, Ericson J, Matise MP, Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS. Development. 2011 Sep;138(17):3711-21
1	J:139698 Wataya T, Ando S, Muguruma K, Ikeda H, Watanabe K, Eiraku M, Kawada M, Takahashi J, Hashimoto N, Sasai Y, Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11796-801
1	J:80206 Wijgerde M, McMahon JA, Rule M, McMahon AP, A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 2002 Nov 15;16(22):2849-64
1	J:143585 Yu W, McDonnell K, Taketo MM, Bai CB, Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner. Development. 2008 Nov;135(22):3687-96
1	J:154982 Yun S, Saijoh Y, Hirokawa KE, Kopinke D, Murtaugh LC, Monuki ES, Levine EM, Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development. 2009 Dec;136(23):3895-906
1*	J:63686 Zhou Y, Yamamoto M, Engel JD, GATA2 is required for the generation of V2 interneurons. Development. 2000 Sep;127(17):3829-38